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Tazobactam acid

CAS No. 89786-04-9

Tazobactam acid( CL-298741 | YTR 830H )

Catalog No. M16459 CAS No. 89786-04-9

Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tazobactam acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.
  • Description
    Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.(In Vitro):Tazobactam (CL-298741) (5 μg/mL; 18 hours) has bactericidal activity and inhibit the growth of the bacteria in a dose-dependent manner.Tazobactam (CL-298741) (1-10 μg/mL; 6 hours; Prot. vulgaris and M. morgan) inhibits various types β-lactamase activity and with ID50 values of ＜ 10 μg/mL, respectively.(In Vivo):Tazobactam (CL-298741) (1000 mg/kg; i.p.; four times a day, for 36 and 84 hours; BALB/c mice) decreases the number of bacteria in mice and survived in low doses.
  • In Vitro
    Tazobactam (CL-298741) (5 μg/mL; 18 hours) has bactericidal activity and inhibit the growth of the bacteria in a dose-dependent manner.Tazobactam (CL-298741) (1-10 μg/mL; 6 hours; Prot. vulgaris and M. morgan) inhibitsvarious types β-lactamase activity and with ID50 values of ＜ 10 μg/mL, respectively.
  • In Vivo
    Tazobactam (CL-298741) (1000 mg/kg; i.p.; four times a day, for 36 and 84 hours; BALB/c mice) decreases the number of bacteria in mice and survived in low doses. Animal Model:BALB/c mice Dosage:1000 mg/kg Administration:Intraperitoneal injection; four times a day, for 36 and 84 hours Result:Decraesed the number of bacteria and neutrophils in BALF than in the control group.
  • Synonyms
    CL-298741 | YTR 830H
  • Pathway
    Microbiology/Virology
  • Target
    Antibiotic
  • Recptor
    β-Lactamase
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    89786-04-9
  • Formula Weight
    300.29
  • Molecular Formula
    C10H12N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Overington JP, et al. Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
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