Fidaxomicin( OPT-80 | PAR-101 )

Catalog No. M16356 CAS No. 873857-62-6

Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	48	In Stock
10MG	38	In Stock
25MG	51	In Stock
50MG	69	In Stock
100MG	117	In Stock
200MG	173	In Stock
500MG	276	In Stock
1G	427	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

Fidaxomicin
Note

Research use only, not for human use.
Brief Description

Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug.
Description

Fidaxomicin(OPT-80; PAR-101) is a new class of narrow spectrum macrocyclic antibiotic drug, selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria.Bacterial Infection Approved(In Vitro):Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024 μg/mL).(In Vivo):Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.
In Vitro

Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).
In Vivo

Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis. Animal Model:Male Golden Syrian hamsters (80-100 g, Hamster model for pseudomembranous colitis)Dosage:0.2, 1, and 5 mg/kg Administration:Orally, once a day for 5 days, beginning 8 h after infectionResult:Completely prevented the lethality of the animals. Completely prevented the development of antibiotic-induced C. difficile colitis in hamsters at doses as low as 0.2 mg/kg.
Synonyms

OPT-80 | PAR-101
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

RNApolymerase
Research Area

Infection
Indication

Bacterial Infection

Chemical Information

CAS Number

873857-62-6
Formula Weight

1058.039
Molecular Formula

C52H74Cl2O18
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 33 mg/mL
SMILES

O=C(O[C@@H]1[C@@H](C)O[C@@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)/C(C)=C/C(C)=C/C[C@@H]([C@H](O)C)OC2=O)[C@@H](OC)[C@H]1O)C4=C(O)C(Cl)=C(O)C(Cl)=C4CC
Chemical Name

Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1