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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - CX-3543

CX-3543

CAS No. 865311-47-3

CX-3543( Quarfloxin | Itarnafloxin )

Catalog No. M16281 CAS No. 865311-47-3

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 223 In Stock
2MG 93 In Stock
5MG 155 In Stock
10MG 250 In Stock
25MG 402 In Stock
50MG 548 In Stock
100MG 732 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    CX-3543
  • Note
    Research use only, not for human use.
  • Brief Description
    CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.
  • Description
    CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.Blood Cancer Phase 2 Discontinued.
  • In Vitro
    Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines.Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.
  • In Vivo
    ——
  • Synonyms
    Quarfloxin | Itarnafloxin
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    865311-47-3
  • Formula Weight
    604.67
  • Molecular Formula
    C35H33FN6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (8.27 mM)
  • SMILES
    O=C(C1=CN2C3=C(C(N4C[C@H](C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
  • Chemical Name
    5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61. 2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32. 3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.
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