KKL-40( KKL40 )

Catalog No. M16279 CAS No. 865285-47-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KKL-40
Note

Research use only, not for human use.
Brief Description

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
Description

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.
In Vitro

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In Vivo

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Synonyms

KKL40
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

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CAS Number

865285-47-8
Formula Weight

351.261
Molecular Formula

C16H9F4N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC(=CC(=C1)C(F)(F)F)C(=O)NC2=NN=C(O2)C3=CC=C(C=C3)F
Chemical Name

N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide

1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.

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