MC-1568( MC1568 )

Catalog No. M16194 CAS No. 852475-26-4

A potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	48	In Stock
5MG	30	In Stock
10MG	49	In Stock
25MG	89	In Stock
50MG	135	In Stock
100MG	244	In Stock
200MG	423	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

MC-1568
Note

Research use only, not for human use.
Brief Description

A potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.
Description

A potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A; displays 176-fold selectivity over HD1-B; increases the accumulation of acetylated H3 and H4 histones in MCF-7 cells at 20 uM; promotes neurite growth and arbourisation and protects neurite arbours against neurotoxic insult.
In Vitro

——
In Vivo

——
Synonyms

MC1568
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HD1-A(Maize)|HD1-B(Maize)
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

852475-26-4
Formula Weight

314.311
Molecular Formula

C17H15FN2O3
Purity

>98% (HPLC)
Solubility

DMSO: 18.5 mg/mL
SMILES

O=C(NO)/C=C/C1=CC=C(/C=C/C(C2=CC=CC(F)=C2)=O)N1C
Chemical Name

2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53. 2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19. 3. Collins LM, et al. Mol Neurobiol. 2015;51(3):1432-42.

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