Valategrast hydrochloride( R-411 | RO-0272441 | RO-27-2441 | R411 | RO 0272441 | RO 27 2441 )

Catalog No. M16076 CAS No. 828271-96-1

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Product Name

Valategrast hydrochloride
Note

Research use only, not for human use.
Brief Description

Valategrast hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.
Description

Valategrast hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.Asthma Discontinued.
In Vitro

Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
In Vivo

——
Synonyms

R-411 | RO-0272441 | RO-27-2441 | R411 | RO 0272441 | RO 27 2441
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

828271-96-1
Formula Weight

641.411
Molecular Formula

C30H33Cl4N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCCN(CC)CC)[C@H](CC1=CC=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=C1)NC(C3=C(C)C=CC=C3Cl)=O.[H]Cl
Chemical Name

2-(diethylamino)ethyl (2S)-2-[(2-chloro-6-methylbenzoyl)amino]-3-[4-[(2,6-dichlorobenzoyl)amino]phenyl]propanoate hydrochloride

1. Sidduri A, et al. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2479-82.

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