Alfuzosin hydrochloride( SL 77499-10 | Uroxatral )

Catalog No. M16039 CAS No. 81403-68-1

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Product Name

Alfuzosin hydrochloride
Note

Research use only, not for human use.
Brief Description

Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
Description

Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).(In Vivo):Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing.
In Vitro

——
In Vivo

Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing. Animal Model:Male Wistar rats (250-450 g).Dosage:10 mg/kg Administration:Oral administration; single.Result:Increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration.
Synonyms

SL 77499-10 | Uroxatral
Pathway

Endocrinology/Hormones
Target

Adrenergic Receptor
Recptor

α-adrenergic receptor
Research Area

Endocrinology
Indication

——

CAS Number

81403-68-1
Formula Weight

425.91
Molecular Formula

C19H27N5O4·HCl
Purity

>98% (HPLC)
Solubility

Ethanol: 85 mg/mL (199.57 mM); Water: 85 mg/mL (199.57 mM); DMSO: 85 mg/mL (199.57 mM)
SMILES

Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N(C)CCCNC(=O)C1CCCO1
Chemical Name

——

1.Kenny BA, et al. Br J Pharmacol. 1996 Jun;118(4):871-8.

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