AA-861( Docebenone )

Catalog No. M16020 CAS No. 80809-81-0

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

AA-861
Note

Research use only, not for human use.
Brief Description

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM.
Description

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM; induces cytotoxic and anti-proliferative effects in 5-LO-positive Capan-2 pancreatic cancer cells; also efficiently inhibits biofilms by preventing the formation of amyloid-like fibers.Allergy Discontinued.
In Vitro

Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently.
In Vivo

Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M.
Synonyms

Docebenone
Pathway

Immunology/Inflammation
Target

Lipoxygenase
Recptor

Lipoxygenase
Research Area

Inflammation/Immunology
Indication

Allergy

Chemical Information

CAS Number

80809-81-0
Formula Weight

326.436
Molecular Formula

C21H26O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (765.86 mM)
SMILES

O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O
Chemical Name

2-(12-hydroxydodeca-5,10-diynyl)- 3,5,6-trimethyl-p-benzoquinone

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Romero D, et al. Chem Biol. 2013 Jan 24;20(1):102-10. 2. Yoshimoto T, et al. Biochim Biophys Acta. 1982 Nov 12;713(2):470-3. 3. Fischer AS, et al. Br J Pharmacol. 2010 Oct;161(4):936-49.

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