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Lenampicillin hydrochloride

CAS No. 80734-02-7

Lenampicillin hydrochloride( KBT-1585 hydrochloride )

Catalog No. M16018 CAS No. 80734-02-7

An efficient prodrug of ampicillin with enhanced absorption and decreased side effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lenampicillin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An efficient prodrug of ampicillin with enhanced absorption and decreased side effects.
  • Description
    An efficient prodrug of ampicillin with enhanced absorption and decreased side effects.
  • In Vitro
    ——
  • In Vivo
    Lenampicillin hydrochloride (KBT-1585)?(oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) areidentified for it main metabolites in rat and dogs. Themain metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver.
  • Synonyms
    KBT-1585 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    80734-02-7
  • Formula Weight
    497.9492
  • Molecular Formula
    C21H24ClN3O7S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N)C3=CC=CC=C3)=O)N1C2=O)OCC4=C(C)OC(O4)=O.[H]Cl
  • Chemical Name
    4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, hydrochloride (1:1), (2S,5R,6R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miki F, et al. Kansenshogaku Zasshi. 1985 Jun;59(6):605-38. 2. Fujita K, et al. Jpn J Antibiot. 1985 Jun;38(6):1423-67. 3. Akimoto Y, et al. Gen Pharmacol. 1991;22(5):797-800.
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