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Home - Products - GPCR/G Protein - Orexin Receptor - SB-334867 free base

SB-334867 free base

CAS No. 792173-99-0

SB-334867 free base( SB334867A free base | SB334867 free base | SB 334867 free base )

Catalog No. M15972 CAS No. 792173-99-0

The first selective Orexin-1 receptor antagonist with pKb of 7.4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 67 In Stock
2MG 33 In Stock
5MG 61 In Stock
10MG 95 In Stock
25MG 155 In Stock
50MG 221 In Stock
100MG 330 In Stock
200MG 491 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SB-334867 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    The first selective Orexin-1 receptor antagonist with pKb of 7.4.
  • Description
    The first selective Orexin-1 receptor antagonist with pKb of 7.4; displays 50-fold selectivity over OX2 (pKb 5.7), >100-fold or selectivity over 5-HT2B, 5-HT2C and approximately 50 other molecular targets, in particular GPCRs and ion channels; possesses CNS penetration, in vivo activity following ip dosing.Obesity Preclinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Swiss mice Dosage:20?mg/kg Administration:Intraperitoneal injectionResult:Inhibited the acquisition of morphine-induced sensitization to locomotor activity of mice.Animal Model:C57BL/6J Mice Dosage:3, 10 and 30 mg/kg Administration:Intraperitoneal injectionResult:Reduced ethanol consumption, BECs and suppressed sucrose intake in mice.
  • Synonyms
    SB334867A free base | SB334867 free base | SB 334867 free base
  • Pathway
    GPCR/G Protein
  • Target
    Orexin Receptor
  • Recptor
    OX1
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    792173-99-0
  • Formula Weight
    319.3174
  • Molecular Formula
    C17H13N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 49 mg/mL
  • SMILES
    CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
  • Chemical Name
    Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Smart D, et al. Br J Pharmacol. 2001 Mar;132(6):1179-82. 2. Porter RA, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10. 3. Rodgers RJ, et al. Eur J Neurosci. 2001 Apr;13(7):1444-52.
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