Cart
sales@molnova.com
Oglemilast
CAS No. 778576-62-8
Oglemilast( GRC 3886 )
Catalog No. M15938 CAS No. 778576-62-8
Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 133 | Get Quote |
|
| 10MG | 228 | Get Quote |
|
| 25MG | 348 | Get Quote |
|
| 50MG | 446 | Get Quote |
|
| 100MG | 651 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameOglemilast
-
NoteResearch use only, not for human use.
-
Brief DescriptionOglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
-
DescriptionOglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.Asthma Phase 1 Discontinued.
-
In VitroOglemilast (GRC 3886) has EC50s of 11.4 nM, 4.4 nM for PDE 4B1 and PDE 4D3 reporter cell lines, respectively.
-
In Vivo——
-
SynonymsGRC 3886
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research AreaInflammation/Immunology
-
IndicationAsthma
Chemical Information
-
CAS Number778576-62-8
-
Formula Weight516.297
-
Molecular FormulaC20H13Cl2F2N3O5S
-
Purity>98% (HPLC)
-
SolubilityDMSO : 4 mg/mL7.75 mM;H2O : < 0.1 mg/mL
-
SMILESO=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl
-
Chemical NameN-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.
molnova catalog
related products
-
Ensifentrine
Ensifentrine is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and COPD and, potentially, cystic fibrosis.
-
Resibufogenin
Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system.
-
BAY 2666605
BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.
