Oglemilast( GRC 3886 )

Catalog No. M15938 CAS No. 778576-62-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Oglemilast
Note

Research use only, not for human use.
Brief Description

Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
Description

Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.Asthma Phase 1 Discontinued.
In Vitro

Oglemilast (GRC 3886) has EC50s of 11.4 nM, 4.4 nM for PDE 4B1 and PDE 4D3 reporter cell lines, respectively.
In Vivo

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Synonyms

GRC 3886
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

778576-62-8
Formula Weight

516.297
Molecular Formula

C20H13Cl2F2N3O5S
Purity

>98% (HPLC)
Solubility

DMSO : 4 mg/mL7.75 mM;H2O : < 0.1 mg/mL
SMILES

O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl
Chemical Name

N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide

1. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.

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