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Oglemilast

CAS No. 778576-62-8

Oglemilast( GRC 3886 )

Catalog No. M15938 CAS No. 778576-62-8

Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Oglemilast
  • Note
    Research use only, not for human use.
  • Brief Description
    Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
  • Description
    Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.Asthma Phase 1 Discontinued.
  • In Vitro
    Oglemilast (GRC 3886) has EC50s of 11.4 nM, 4.4 nM for PDE 4B1 and PDE 4D3 reporter cell lines, respectively.
  • In Vivo
    ——
  • Synonyms
    GRC 3886
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    778576-62-8
  • Formula Weight
    516.297
  • Molecular Formula
    C20H13Cl2F2N3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 4 mg/mL7.75 mM;H2O : < 0.1 mg/mL
  • SMILES
    O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl
  • Chemical Name
    N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.
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