103D5R( —— )

Catalog No. M15924 CAS No. 773852-25-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

103D5R
Note

Research use only, not for human use.
Brief Description

103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
Description

103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity; shows cell proliferation under normoxia in LN229 cell with IC50 of 26 uM, markedly decreases HIF-1α protein synthesis induced by hypoxia or cobaltous ions in a dose- and time-dependent manner; inhibits phosphorylation of Akt, SAPK/JNK and Erk1/2, prevents the activation of HIF-1 target genes under hypoxia such as VEGF and Glut-1.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF/HIF Prolyl-hydroxylase
Research Area

——
Indication

——

CAS Number

773852-25-8
Formula Weight

335.407
Molecular Formula

C20H21N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl]-1H-imidazo[4,5-b]pyridine

1. Tan C, et al. Cancer Res. 2005 Jan 15;65(2):605-12. 2. Belozerov VE, et al. Anticancer Drugs. 2005 Oct;16(9):901-9.

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