Cart
sales@molnova.com
Isradipine
CAS No. 75695-93-1
Isradipine( PN 200-110 )
Catalog No. M15878 CAS No. 75695-93-1
Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 30 | In Stock |
|
| 10MG | 49 | In Stock |
|
| 25MG | 88 | In Stock |
|
| 50MG | 146 | In Stock |
|
| 100MG | 243 | In Stock |
|
| 500MG | 601 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIsradipine
-
NoteResearch use only, not for human use.
-
Brief DescriptionIsradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.
-
DescriptionIsradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.(In Vitro):Isradipine has much higher (＞40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels.(In Vivo):Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner.Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine.
-
In VitroIsradipine has much higher (＞40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels.
-
In VivoIsradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner.Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine. Animal Model:Rats Dosage:0.1~3 mg/kg Administration:P.o.Result:Sodium excretion increased in a dose-dependent manner. ?
-
SynonymsPN 200-110
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research AreaCardiovascular Disease
-
Indication——
Chemical Information
-
CAS Number75695-93-1
-
Formula Weight371.39
-
Molecular FormulaC19H21N3O5
-
Purity>98% (HPLC)
-
SolubilityEthanol: 74 mg/mL warmed (199.25 mM); DMSO: 74 mg/mL (199.25 mM)
-
SMILESCC1=C(C(OC)=O)C(C2=CC=CC3=NON=C32)C(C(OC(C)C)=O)=C(C)N1
-
Chemical Name3-isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ilijic E, et al. Neurobiol Dis. 2011 Aug;43(2):364-7
molnova catalog
related products
-
Mirogabalin
Mirogabalin (DS-5565) is a novel potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.
-
Pranidipine
Pranidipine is a novel, long-acting 1,4-dihydropyridine calcium channel blocker.
-
PD 0299685
PD 0299685 is a potent α2δ ligand of the Ca2+ channel for the treatment of interstitial cystitis.
