Ponalrestat( ICI 128436 | MK-538 | Ponalrestat )

Catalog No. M15783 CAS No. 72702-95-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Ponalrestat
Note

Research use only, not for human use.
Brief Description

ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice
Description

ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice.
In Vitro

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In Vivo

Animal Model:Adult female Sprague-Dawley ratsDosage:10, 50 mg/kg Administration:Orally; daily; 8 weeks Result:Reduced sorbitol accumulation.
Synonyms

ICI 128436 | MK-538 | Ponalrestat
Pathway

Endocrinology/Hormones
Target

Reductase
Recptor

Aldose reductase
Research Area

——
Indication

——

CAS Number

72702-95-5
Formula Weight

391.19
Molecular Formula

C17H12BrFN2O3
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

O=C(O)CC1=NN(CC2=CC=C(Br)C=C2F)C(C3=C1C=CC=C3)=O
Chemical Name

2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

1.Pekiner C, McLean WG. Br J Pharmacol. 1990 Dec;101(4):978-80.

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