Metoclopramide hydrochloride

Research use only, not for human use.

Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.(In Vitro):Metoclopramide (0.01-10 μM) hydrochloride hydrate stimulates aldosterone release in isolated perfused rat zona glomerulosa cells.Metoclopramide hydrochloride hydrate results in prokinesis by four mechanisms: inhibition of presynaptic D2 receptors and stimulation of presynaptic excitatory 5-HT4 receptors, thereby allowing acetylcholine (ACh) release from intrinsic cholinergic motor neurons; inhibition of D2 postsynaptic receptors; and antagonism of the presynaptic inhibition of muscarinic receptors, leading to further augmentation of ACh release.(In Vivo):Metoclopramide (6.7 μg/g; s.c. daily for 50 days) hydrochloride hydrate significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle.Metoclopramide (5-40 mg/kg; i.p.) hydrochloride hydrate induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice.Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride hydrate induces stereotyped cage climbing behaviour in mice.

Metoclopramide (0.01-10 μM) hydrochloride stimulates aldosterone release in isolated perfused rat zona glomerulosa cells.Metoclopramide hydrochloride results in prokinesis by four mechanisms: inhibition of presynaptic D2 receptors and stimulation of presynaptic excitatory 5-HT4 receptors, thereby allowing acetylcholine (ACh) release from intrinsic cholinergic motor neurons; inhibition of D2 postsynaptic receptors; and antagonism of the presynaptic inhibition of muscarinic receptors, leading to further augmentation of ACh release.

Metoclopramide (6.7 μg/g; s.c. daily for 50 days) hydrochloride significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle.Metoclopramide (5-40 mg/kg; i.p.) hydrochloride induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice.Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride induces stereotyped cage climbing behaviour in mice. Animal Model:Adult, virgin female mice of the Swiss EPM-1 strain Dosage:6.7 μg/g Administration:S.c. daily for 50 days Result:Increased the number but also stimulated the metabolic activity of lactotrophs.

NSC 354467

Endocrinology/Hormones

5-HT Receptor

5-HT| mAChR| Dopamine

Other Indications

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7232-21-5

336.26

C14H22ClN3O2·HCl

>98% (HPLC)

Ethanol: 67 mg/mL (199.25 mM); Water: 67 mg/mL (199.25 mM); DMSO: 67 mg/mL warmed (199.25 mM)

Cl.CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC

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(-20℃)

With Ice Pack

≥ 2 years