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Artemether

CAS No. 71963-77-4

Artemether( Falcidol | Larither | Malartem | Paluther | SM-224 )

Catalog No. M15754 CAS No. 71963-77-4

Artemether is an antimalarial agent used to treat acute uncomplicated malaria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
25MG 29 In Stock
50MG 37 In Stock
100MG 51 In Stock
200MG Get Quote In Stock
500MG 66 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Artemether
  • Note
    Research use only, not for human use.
  • Brief Description
    Artemether is an antimalarial agent used to treat acute uncomplicated malaria.
  • Description
    Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
  • In Vitro
    Western Blot Analysis Cell Line:RAW264.7 cells (treated with 100?ng/mL RANKL) Concentration:10 μM Incubation Time:6 h Result:Inhibited the activation of MAPK subfamilies, including ERK, JNK, and p38.Cell Cycle Analysis Cell Line:ConA-stimulated T lymphocytes Concentration:1, 10 and 50?μM Incubation Time:72 h Result:Arrested 47, 56 and 91% (at 1, 10 and 50?μM) of the cells at G0/G1 phases, respectively.
  • In Vivo
    Animal Model:LPS (5 mg/kg) treated mice Dosage:10 mg/kg Administration:i.p., 8 days Result:Prevented LPS induced osteolytic bone loss and the reduction in bone volume. Increased bone volume/total volume (BV/TV), decreased osteoclast surface/bone surface (Oc.S/BS) and number of TRAP-positive cells.
  • Synonyms
    Falcidol | Larither | Malartem | Paluther | SM-224
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    71963-77-4
  • Formula Weight
    298.38
  • Molecular Formula
    C16H26O5
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 60 mg/mL (201.09 mM); DMSO: 60 mg/mL (201.09 mM)
  • SMILES
    C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C
  • Chemical Name
    (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ma Y, et al. Antimicrob Agents ChemOthers. 2014 Oct;58(10):5658-65.
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