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Elubrixin

CAS No. 688763-64-6

Elubrixin( SB-656933 | GSK-656933 )

Catalog No. M15632 CAS No. 688763-64-6

Elubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Elubrixin
  • Note
    Research use only, not for human use.
  • Brief Description
    Elubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
  • Description
    Elubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist; inhibits CXCL1-induced CD11b up-regulation on PMNs in an in vitro whole blood assay and to be active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.Fibrosis,Phase 2 Discontinued.
  • In Vitro
    Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion.
  • In Vivo
    ——
  • Synonyms
    SB-656933 | GSK-656933
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Other Indications
  • Indication
    Fibrosis

Chemical Information

  • CAS Number
    688763-64-6
  • Formula Weight
    463.305
  • Molecular Formula
    C17H17Cl2FN4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
  • Chemical Name
    1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. 2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9. 3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80. 4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.
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