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Elubrixin
CAS No. 688763-64-6
Elubrixin( SB-656933 | GSK-656933 )
Catalog No. M15632 CAS No. 688763-64-6
Elubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 267 | In Stock |
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| 5MG | 249 | In Stock |
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| 10MG | 369 | In Stock |
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| 25MG | 562 | In Stock |
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| 50MG | 770 | In Stock |
|
| 100MG | 1032 | In Stock |
|
| 200MG | 1376 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameElubrixin
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NoteResearch use only, not for human use.
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Brief DescriptionElubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
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DescriptionElubrixin (SB-656933;GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist; inhibits CXCL1-induced CD11b up-regulation on PMNs in an in vitro whole blood assay and to be active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.Fibrosis,Phase 2 Discontinued.
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In VitroElubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion.
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In Vivo——
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SynonymsSB-656933 | GSK-656933
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaOther Indications
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IndicationFibrosis
Chemical Information
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CAS Number688763-64-6
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Formula Weight463.305
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Molecular FormulaC17H17Cl2FN4O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
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Chemical Name1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.
2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9.
3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80.
4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.
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