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Home - Products - PI3K/Akt/mTOR signaling - GSK-3 - 1-Azakenpaullone

1-Azakenpaullone

CAS No. 676596-65-9

1-Azakenpaullone( 1-Azakenpaullone )

Catalog No. M15585 CAS No. 676596-65-9

1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    1-Azakenpaullone
  • Note
    Research use only, not for human use.
  • Brief Description
    1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM.
  • Description
    1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM); stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells.
  • In Vitro
    Real Time qPCR Cell Line:human MSCs Concentration:3 μM Incubation Time:48 hResult:Increased gene expression of osteoblast-specific marker genes (ALP, OC, ON, COL1A1, and OPN).
  • In Vivo
    ——
  • Synonyms
    1-Azakenpaullone
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3β
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    676596-65-9
  • Formula Weight
    328.169
  • Molecular Formula
    C15H10BrN3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 61 mg/mL (185.9 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4
  • Chemical Name
    9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kunick C, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. 2. Mishra R, et al. J Biol Chem. 2007 Oct 19;282(42):30393-405. 3. Mfopou JK, et al. Stem Cell Res. 2014 Jan;12(1):166-77. 4. Liu H, et al. Diabetes. 2009 Mar;58(3):663-72.
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