Cart
sales@molnova.com
Sembragiline
CAS No. 676479-06-4
Sembragiline( RO4602522 | RG1577 | EVT 302 )
Catalog No. M15584 CAS No. 676479-06-4
Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1798 | Get Quote |
|
| 50MG | 5778 | Get Quote |
|
| 100MG | 8928 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSembragiline
-
NoteResearch use only, not for human use.
-
Brief DescriptionSembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM.
-
DescriptionSembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A; displays no affinity for more than 100 different receptors, enzymes and ion channels; protects against neuronal loss and reduces both ROS formation and reactive astrogliosis in transgenic animal model conditionally overexpressing MAO-B in astroglia, exhibits potential for treatment of Alzheimer's disease (AD) and other neurodegenerative disorders.Alzheimer Disease Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsRO4602522 | RG1577 | EVT 302
-
PathwayMetabolic Enzyme/Protease
-
TargetMAO
-
RecptorMAO
-
Research AreaNeurological Disease
-
IndicationAlzheimer Disease
Chemical Information
-
CAS Number676479-06-4
-
Formula Weight342.37
-
Molecular FormulaC19H19FN2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(N[C@@H](C1)CN(C2CCC(OCC3=CC=CC(F)=C3)CC2)C1=O)=O
-
Chemical Name(3S)-N-{1-[4-(3-fluorobenzyloxy)-phenyl]-5-oxo-pyrrolidin-3-yl} acetamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Borroni E, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):413-423.
2. Nave S, et al. J Alzheimers Dis. 2017;58(4):1217-1228.
3. Yeon SK, et al. Bioorg Med Chem. 2018 Jan 1;26(1):232-244.
molnova catalog
related products
-
Femoxetine
Femoxetine is a 5-HT inhibitor with antidepressant activity that potentiates morphine-induced anti-injury feelings and inhibits MAO-A and MAO-B required for the production of high exercise capacity in mice.
-
Nialamide
An MAO inhibitor that is used as an antidepressive agent.
-
Amiflamine
Amiflamine is an inhibitor of reversible MAO-A.The ex vivo approach was found to be valid for moclobemide in brain and liver and for cimoxatone in brain tissue;?a slight underestimation of the MAO A inhibitory effect of the latter in the liver is likely.?
