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Sembragiline
CAS No. 676479-06-4
Sembragiline( RO4602522 | RG1577 | EVT 302 )
Catalog No. M15584 CAS No. 676479-06-4
Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1264 | In Stock |
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| 5MG | 1891 | In Stock |
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| 10MG | 2803 | In Stock |
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| 25MG | 4684 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSembragiline
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NoteResearch use only, not for human use.
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Brief DescriptionSembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM.
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DescriptionSembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A; displays no affinity for more than 100 different receptors, enzymes and ion channels; protects against neuronal loss and reduces both ROS formation and reactive astrogliosis in transgenic animal model conditionally overexpressing MAO-B in astroglia, exhibits potential for treatment of Alzheimer's disease (AD) and other neurodegenerative disorders.Alzheimer Disease Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsRO4602522 | RG1577 | EVT 302
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PathwayMetabolic Enzyme/Protease
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TargetMAO
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RecptorMAO
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number676479-06-4
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Formula Weight342.37
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Molecular FormulaC19H19FN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(N[C@@H](C1)CN(C2CCC(OCC3=CC=CC(F)=C3)CC2)C1=O)=O
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Chemical Name(3S)-N-{1-[4-(3-fluorobenzyloxy)-phenyl]-5-oxo-pyrrolidin-3-yl} acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Borroni E, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):413-423.
2. Nave S, et al. J Alzheimers Dis. 2017;58(4):1217-1228.
3. Yeon SK, et al. Bioorg Med Chem. 2018 Jan 1;26(1):232-244.
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