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Ilepatril
CAS No. 669764-02-7
Ilepatril( AVE 7688 | AVE7688 )
Catalog No. M15556 CAS No. 669764-02-7
A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameIlepatril
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively.
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DescriptionA potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively; displays good in vitro selectivity over a large variety of targets; restores endothelial function by increasing the ratio of NO to O2- concentration and bioavailability of NO, prevents albuminuria and reduces the incidence and severity of glomerulosclerosis and tubulointerstitial damage in vivo.Hypertension Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAVE 7688 | AVE7688
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PathwayMetabolic Enzyme/Protease
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TargetACE
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RecptorACE
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number669764-02-7
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Formula Weight418.508
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Molecular FormulaC21H26N2O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC(C(=O)NC1CC2=CC=CC=C2C3CCCC(N3C1=O)C(=O)O)SC(=O)C
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Chemical Name7-[[(2S)-2-(acetylthio)-1-oxo-3-methylpropyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-(4S,7S,12bR)-pyrido[2,1-a][2]benzazepine-4-carboxic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Weckler N, et al. J Renin Angiotensin Aldosterone Syst. 2003 Sep;4(3):191-6.
2. Sch?fer S, et al. Cardiovasc Res. 2003 Nov 1;60(2):447-54.
3. Sch?fer S, et al. Diabetologia. 2004 Jan;47(1):98-103.
4. Sch?fer S, et al. Eur J Pharmacol. 2004 Jan 26;484(2-3):361-2.
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