Cart
sales@molnova.com
Home - Products - Microbiology/Virology - Parasite - Arterolane

Arterolane

CAS No. 664338-39-0

Arterolane( OZ277 | RBx 11160 )

Catalog No. M15532 CAS No. 664338-39-0

Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 312 Get Quote
50MG 1224 Get Quote
100MG 1971 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Arterolane
  • Note
    Research use only, not for human use.
  • Brief Description
    Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.
  • Description
    Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.Parasite Infection Phase 2 Discontinued.
  • In Vitro
    Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively.
  • In Vivo
    ——
  • Synonyms
    OZ277 | RBx 11160
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    Infection
  • Indication
    Parasite Infection

Chemical Information

  • CAS Number
    664338-39-0
  • Formula Weight
    392.54
  • Molecular Formula
    C22H36N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 254.76 mM
  • SMILES
    O=C(NCC(C)(N)C)CC(CC1)CCC21OC3(OO2)C4CC5CC(C4)CC3C5
  • Chemical Name
    N-(2-amino-2-methylpropyl)-2-{dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-cyclohexane]-4''-yl}acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kreidenweiss A, et al. Antimicrob Agents Chemother. 2006 Apr;50(4):1535-7. 2. Vennerstrom JL, et al. Nature. 2004 Aug 19;430(7002):900-4. 3. Maerki S, et al. J Antimicrob Chemother. 2006 Jul;58(1):52-8. 4. Snyder C, et al. Exp Parasitol. 2007 Mar;115(3):296-300.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Chlorin E6

    Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation.

  • ELQ-300

    ELQ-300 is bioavailable antimalarial agent acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1).

  • Ganaplacide

    Ganaplacide (KAF156, GNF-156)?is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.

Sign In Join Free