Cart
sales@molnova.com
Home - Products - Others - Other Targets - Perhexiline

Perhexiline

CAS No. 6621-47-2

Perhexiline( —— )

Catalog No. M15523 CAS No. 6621-47-2

Perhexiline is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1229 Get Quote
50MG 2507 Get Quote
100MG 3168 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Perhexiline
  • Note
    Research use only, not for human use.
  • Brief Description
    Perhexiline is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2).
  • Description
    Perhexiline is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2); promotes HER3 ablation through receptor internalization and inhibits tumor growth; activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.Hypertension Phase 2 Clinical.
  • In Vitro
    Perhexiline (5-25 μM, 2-6 h) reduces cell viability in HepG2 cells.Perhexiline (5-25 μM, 2-6 h) reduces cellular ATP content and Lactate dehydrogenase (LDH) release in HepG2 cells.Perhexiline (20 μM, 2 h) activates caspase 3/7 in HepG2 cells.Perhexiline (5-25 μM, 4 h) causes mitochondrial dys function in HepG2 cells.Perhexiline (5 μM, 48 h) selectively induces massive apoptosis in CLL cells (high expression of CPT). Cell Viability Assay Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2, 4, 6 h Result:Induced time- and concentration-dependent cytotoxicity in hepatic cells.Western Blot Analysis Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2 h Result:Reduced Bcl-2 and Mcl-1 level, and increased Bad level.
  • In Vivo
    Perhexiline (200 mg/kg, p.o., daily for 8 weeks) reduces peripheral neural function in female DA rats.Perhexiline (80 mg/kg, oral gavage, for 3 days) demonstrates anti-tumor activity in glioblastoma mouse model. Animal Model:Orthotopic glioblastoma mouse model Dosage:80 mg/kg Administration:Oral gavage, for 3 days. Result:Reduces tumor size (MR imaging) and improves in overall survival.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypertension

Chemical Information

  • CAS Number
    6621-47-2
  • Formula Weight
    277.496
  • Molecular Formula
    C19H35N
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
  • Chemical Name
    2-(2,2-dicyclohexylethyl)-piperidine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guo Y, et al. J Clin Invest. 2015 Oct 1;125(10):3819-30. 2. Hamdan M, et al. Pharmacol Res. 2001 Aug;44(2):99-104. 3. Ren XR, et al. Breast Cancer Res. 2015 Feb 15;17:20.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • WZ3146

    WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).

  • Murine CMV pp 89 (16...

    IE1 peptide refers to an antigenic peptide encoded by the immediate early (IE) gene of mouse cytomegalovirus (mCMV). IE1 peptide is one of the key antigenic peptides expressed during mCMV infection, plays a role in transcriptional activation in the life cycle of mCMV, and is one of the earliest genes expressed in the viral replication cycle. IE1 peptide is an important target for CD8+ T cell response and can be used to study the host immune response to mCMV infection.

  • pGlu-Pro-Arg-MNA mon...

    pGlu-Pro-Arg-MNA monoacetate is a thrombin substrate which has been modeled after a thrombin cleavage site in human fibrinogen, can be used for a sensitive assay of antithrombin III activity.

Sign In Join Free