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SirT1 enhancer A03
CAS No. 66171-75-3
SirT1 enhancer A03( Alaproclate, (S)- | (-)-Alaproclate | S-(-)-Alaproclate )
Catalog No. M15521 CAS No. 66171-75-3
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSirT1 enhancer A03
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NoteResearch use only, not for human use.
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Brief DescriptionSirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
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DescriptionSirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity.
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In Vitro——
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In Vivo——
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SynonymsAlaproclate, (S)- | (-)-Alaproclate | S-(-)-Alaproclate
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin
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Research Area——
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Indication——
Chemical Information
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CAS Number66171-75-3
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Formula Weight255.742
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Molecular FormulaC13H18ClNO2
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Purity>98% (HPLC)
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Solubility——
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SMILESN[C@@H](C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O
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Chemical Name1-(4-chlorophenyl)-2-methylpropan-2-yl alaninate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574.
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