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Nanchangmycin

CAS No. 65101-87-3

Nanchangmycin( Nanchangmycin A )

Catalog No. M15472 CAS No. 65101-87-3

A polyether ionophore antibiotic isolated from Streptomyces nanchangensis NS3226 that shows antibacterial and antiviral properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 206 In Stock
5MG 132 In Stock
10MG 211 In Stock
25MG 424 In Stock
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Biological Information

  • Product Name
    Nanchangmycin
  • Note
    Research use only, not for human use.
  • Brief Description
    A polyether ionophore antibiotic isolated from Streptomyces nanchangensis NS3226 that shows antibacterial and antiviral properties.
  • Description
    A polyether ionophore antibiotic isolated from Streptomyces nanchangensis NS3226 that shows antibacterial and antiviral properties; A potent inhibitor of Zika virus entry, also is active against other medically relevant viruses, including West Nile, dengue, and chikungunya viruses.
  • In Vitro
    Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types.
  • In Vivo
    ——
  • Synonyms
    Nanchangmycin A
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    65101-87-3
  • Formula Weight
    889.0956
  • Molecular Formula
    C47H77NaO14
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 26 mg/mL
  • SMILES
    C[C@H]([C@@H](O1)[C@H](C)[C@@H](O)C[C@@]21CC[C@@](C)([C@@H](C[C@H](OC3O[C@H](C)[C@@H](OC)CC3)[C@H]4C)O[C@]54[C@@H](C)C[C@H]([C@H]6O[C@](CO)(O)[C@H](C)C[C@@H]6C)O5)O2)/C=C(C)/C([C@H](C)C[C@H](C)C([O-])=O)=O.[Na+]
  • Chemical Name
    6-Nonenoic acid, 8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu T, et al. Chem Biol. 2008 May;15(5):449-58. 2. Liu T, et al. Chem Biol. 2006 Sep;13(9):945-55. 3. Rausch K, et al. Cell Rep. 2017 Jan 17;18(3):804-815.
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