Guanethidine Monosulfate

Research use only, not for human use.

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.(In Vivo):Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes.

——

Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes. Animal Model:Male Wistar rats (approximately 200 g) Dosage:5 mg/kg or 40 mg/kg Administration:Intraperitoneal injection; daily; for 4, 8, 14, or 28 days Result:Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.

——

Neuroscience

Norepinephrine

Norepinephrine (NE)

Neurological Disease

——

645-43-2

296.39

C10H24N4O4S

>98% (HPLC)

Soluble in Water

OS(O)(=O)=O.NC(N)=NCCN1CCCCCCC1

——

(-20℃)

With Ice Pack

≥ 2 years