Imipenem

Research use only, not for human use.

Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria.

Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.Bacterial Infection Phase 3 Clinical(In Vivo):Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single).

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Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single).Animal Model:Neutropenic mouse model of biofilm lung infection Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.

MK-0787

GPCR/G Protein

Antibacterial

Antibacterial

Infection

Bacterial Infection

64221-86-9

299.345

C12H17N3O4S

>98% (HPLC)

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CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O

(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years