Oxiconazole nitrate

Research use only, not for human use.

Oxiconazole nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm.

Oxiconazole nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. (In Vitro):Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth.Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton.(In Vivo):Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth.

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth.Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton.Antifungal Activities of Oxiconazole.Cell Proliferation Assay Cell Line:HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 Concentration:0-40 μM Incubation Time:24 h Result:Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth. Animal Model:BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)Dosage:50 mg/kg/day Administration:IP; for 12 days Result:Significantly restrained CRC cell growth and showed no obvious side effects.

Ro 13-8996

Microbiology/Virology

Antifection

14-α Demethylase| LSS

Infection

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64211-46-7

492.14

C18H13Cl4N3O·HNO3

>98% (HPLC)

DMSO: 10 mM

C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]

——

(-20℃)

With Ice Pack

≥ 2 years