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BRD6989

CAS No. 642008-81-9

BRD6989( BRD-6989 | BRD 6989 )

Catalog No. M15440 CAS No. 642008-81-9

A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 88 Get Quote
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Biological Information

  • Product Name
    BRD6989
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).
  • Description
    A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BRD-6989 | BRD 6989
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    642008-81-9
  • Formula Weight
    264.332
  • Molecular Formula
    C16H16N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (94.58 mM)
  • SMILES
    CC1CCC2=C(C1)C(=C(C(=N2)N)C#N)C3=CN=CC=C3
  • Chemical Name
    2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.
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