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GANT 58
CAS No. 64048-12-0
GANT 58( NSC 75503 | GANT58 | GANT-58 | NSC-75503 )
Catalog No. M15435 CAS No. 64048-12-0
GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 113 | In Stock |
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| 50MG | 183 | In Stock |
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| 100MG | 296 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGANT 58
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NoteResearch use only, not for human use.
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Brief DescriptionGANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
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DescriptionGANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM; efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth in an in vivo xenograft model of human prostate cancer cells harboring downstream activation of the Hh pathway.
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In Vitro——
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In Vivo——
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SynonymsNSC 75503 | GANT58 | GANT-58 | NSC-75503
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PathwayWnt/Notch/Hedgehog
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TargetGli
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RecptorGli
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number64048-12-0
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Formula Weight392.47564
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Molecular FormulaC24H16N4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1(C2=CC=NC=C2)=C(C3=CC=NC=C3)C(C4=CC=NC=C4)=C(C5=CC=NC=C5)S1
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Chemical NamePyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lauth M, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.
2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.
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