TP003( TP 003 )

Catalog No. M15377 CAS No. 628690-75-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TP003
Note

Research use only, not for human use.
Brief Description

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2.
Description

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM); produces a robust anxiolytic-like effect in both rodent and non-human primate behavioral models of anxiety, also retains efficacy in a stress-induced hyperthermia model.Epilepsy Discontinued.
In Vitro

——
In Vivo

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Synonyms

TP 003
Pathway

Membrane Transporter/Ion Channel
Target

GAT
Recptor

GAT
Research Area

Neurological Disease
Indication

Epilepsy

CAS Number

628690-75-5
Formula Weight

407.396
Molecular Formula

C23H16F3N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (245.47 mM)
SMILES

N#CC1=CC(F)=CC=C1C2=CC(C3=CN=C4C(F)=C(C(C)(O)C)C=CN43)=CC=C2F
Chemical Name

2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile

1. Dias R, et al. J Neurosci. 2005 Nov 16;25(46):10682-8. 2. Fradley RL, et al. J Psychopharmacol. 2007 Jun;21(4):384-91.

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