Cart
sales@molnova.com
Rolipram
CAS No. 61413-54-5
Rolipram( SB95952 | ZK62711 | (R,S)-Rolipram | SB 95952 | ZK 62711 | SB-95952 | ZK-62711 )
Catalog No. M15314 CAS No. 61413-54-5
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 10MG | 41 | In Stock |
|
| 50MG | 57 | In Stock |
|
| 100MG | 81 | In Stock |
|
| 200MG | 119 | In Stock |
|
| 500MG | 197 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRolipram
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
-
DescriptionA potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.Asthma Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsSB95952 | ZK62711 | (R,S)-Rolipram | SB 95952 | ZK 62711 | SB-95952 | ZK-62711
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE4B|PDE4D
-
Research AreaInflammation/Immunology
-
IndicationAsthma
Chemical Information
-
CAS Number61413-54-5
-
Formula Weight275.3428
-
Molecular FormulaC16H21NO3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 41 mg/mL
-
SMILESO=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
-
Chemical Name2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.
2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.
3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
molnova catalog
related products
-
Verofylline
Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the treatment of asthma disease research obesity.
-
AMG-579
AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
-
Avanafil
A potent and highly selective PDE5 inhibitor (IC50=5.2 nM) for erectile dysfunction.
