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Teicoplanin

CAS No. 61036-62-2

Teicoplanin( Antibiotic 8327A | Antibiotic MDL 507 | MDL 507 )

Catalog No. M15294 CAS No. 61036-62-2

Teicoplanin is a semisynthetic glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Teicoplanin
  • Note
    Research use only, not for human use.
  • Brief Description
    Teicoplanin is a semisynthetic glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria.
  • Description
    Teicoplanin is a semisynthetic glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus faecalis.
  • In Vitro
    ——
  • In Vivo
    Animal Model:20-30 g, Male CD1 mice (2?*?106 cfu/mL MRSA (43?300) 50 μL; murine thigh infection model)Dosage:10, 30 mg/kg Administration:I.v.; once every 12?h Result:Showed a dose-dependent decline in the total bacterial density with the total bactericidal effect was achieved with dosages of ≥10?mg/kg/day and suppression of resistance with dosages ≥30?mg/kg/day.
  • Synonyms
    Antibiotic 8327A | Antibiotic MDL 507 | MDL 507
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    61036-62-2
  • Formula Weight
    1709.39
  • Molecular Formula
    C77H77N5O31CI2R
  • Purity
    >98% (HPLC)
  • Solubility
    Water: 100 mg/mL (58.5 mM)
  • SMILES
    CCCCCCCCC/C(O)=N/[C@]([C@@](OC1=C2C=C([C@](/N=C(O)\[C@](/N=C(O)/[C@@](/N=C(O)\[C@@](N)([H])C3=CC4=C(O)C=C3)([H])CC5=CC(Cl)=C(O2)C=C5)([H])C6=CC(O)=CC(O4)=C6)([H])/C(O)=N/[C@](/C(O)=N/7)([H])C8=CC(C9=C([C@@]%10([H])C(O)=O)C=C(O)C=C9OC%11([H])[C@](O)([H])[C@](O)([H])[C@@](O)([H])[C@@](O%11)([H])CO)=C(O)C=C8)C=C1OC%12=C(Cl)C=C([C@](O[C@@]%13([H])[C@@](/N=C(O)/C)([H])[C@](O)([H])[C@@](O)([H])[C@@](O%13)([H])CO)([H])[C@@]7([H])/C(O)=N/%10)C=C%12)([H])O%14)([H])[C@](O)([H])[C@@](O)([H])[C@@]%14([H])CO
  • Chemical Name
    34-O-[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-.beta.-D-glucopyranosyl]-42-O-.alpha.-D-mannopyranosyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bereczki I, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3251-4.
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