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TWS119

CAS No. 601514-19-6

TWS119( TWS 119 | TWS-119 )

Catalog No. M15239 CAS No. 601514-19-6

A GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 45 In Stock
5MG 41 In Stock
10MG 67 In Stock
25MG 130 In Stock
50MG 235 In Stock
100MG 406 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    TWS119
  • Note
    Research use only, not for human use.
  • Brief Description
    A GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs.
  • Description
    A GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs; reduces Cdon levels and aberrant Cx43 activitiesin rat cardiomyocytes; attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TWS 119 | TWS-119
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3β
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    601514-19-6
  • Formula Weight
    318.3293
  • Molecular Formula
    C18H14N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
  • Chemical Name
    Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ding S, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7. 2. Wang W, et al. Mol Neurobiol. 2016 Dec;53(10):7028-7036. 3. Jeong MH, et al. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1345-E1354.
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