Cart
sales@molnova.com
TWS119
CAS No. 601514-19-6
TWS119( TWS 119 | TWS-119 )
Catalog No. M15239 CAS No. 601514-19-6
A GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 45 | In Stock |
|
| 5MG | 41 | In Stock |
|
| 10MG | 67 | In Stock |
|
| 25MG | 130 | In Stock |
|
| 50MG | 235 | In Stock |
|
| 100MG | 406 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTWS119
-
NoteResearch use only, not for human use.
-
Brief DescriptionA GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs.
-
DescriptionA GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs; reduces Cdon levels and aberrant Cx43 activitiesin rat cardiomyocytes; attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats.
-
In Vitro——
-
In Vivo——
-
SynonymsTWS 119 | TWS-119
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorGSK-3β
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number601514-19-6
-
Formula Weight318.3293
-
Molecular FormulaC18H14N4O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESC1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
-
Chemical NamePhenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ding S, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7.
2. Wang W, et al. Mol Neurobiol. 2016 Dec;53(10):7028-7036.
3. Jeong MH, et al. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1345-E1354.
molnova catalog
related products
-
Sulfaphenazole
Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
-
PF-04802367
A potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays.
-
Indirubin-3'-monoxim...
A potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo.
