Malotilate

Research use only, not for human use.

Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.

Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.(In Vitro):Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.(In Vivo):Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol.

Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.

Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol. Animal Model:Male rats of the SLC-SD strain (rats with carbon tetrachloride-induced liver damage)Dosage:100 mg/kg Administration:P.o.; daily for 3 days Result:The triglyceride secretion from livers in rats given CCI4 was inhibited to about 40% of the level in the control rats. This inhibition of the triglyceride secretion was completely normalized in response to malotilate administration for 3 days.

Malotilate | CL-1500 | NKK 105 | NKK-105

Others

Other Targets

Others

Cancer

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59937-28-9

288.38

C12H16O4S2

>98% (HPLC)

Ethanol: 58 mg/mL (201.12 mM); DMSO: 58 mg/mL (201.12 mM)

O=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS/1

1,3-Dithiol-2-ylidenepropanedioic acid, bis(1-methylethyl) ester

(-20℃)

With Ice Pack

≥ 2 years