Piperacillin sodium salt( CL 227,193 | T-1220 )

Catalog No. M15217 CAS No. 59703-84-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Piperacillin sodium salt
Note

Research use only, not for human use.
Brief Description

Piperacillin is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
Description

Piperacillin is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
In Vitro

——
In Vivo

Animal Model:BALB/c low inoculum model of K. pneumoniae, KEN-11 strain Dosage:100 mg/kg Administration:Intravenous injection (i.v.), 4 times a day, 5 d, in combination with Tazobactam (12.5 mg/kg, i.v., 4 times a day, 5 d)Result:Enabled all mice survived whereas all control mice died by 5 d, decreased the number of bacteria in lungs compared with control group[. Observed no bacteria in the blood of most mice (except for two mice at the early phase) while bacteria were observed in the blood of control group. Observed few inflammatory cells in the alveoli whereas an influx of numerous inflammatory cells were observed in the control group.
Synonyms

CL 227,193 | T-1220
Pathway

Microbiology/Virology
Target

Antibiotic
Recptor

β-Lactamase
Research Area

Infection
Indication

——

CAS Number

59703-84-3
Formula Weight

539.54
Molecular Formula

C23H26N5NaO7S
Purity

>98% (HPLC)
Solubility

Ethanol: 100 mg/mL (185.34 mM); Water: 100 mg/mL (185.34 mM); DMSO: 100 mg/mL (185.34 mM)
SMILES

CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
Chemical Name

sodium;(2S,5R,6R)-6-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

1.Williamson R, et al. Antimicrob Agents ChemOthers, 1980, 18(4), 629-637.

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