Cart
sales@molnova.com
Pyrimethamine
CAS No. 58-14-0
Pyrimethamine( Pirimecidan | Pirimetamin | RP 4753 )
Catalog No. M15132 CAS No. 58-14-0
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 50MG | 35 | In Stock |
|
| 100MG | 48 | In Stock |
|
| 200MG | 73 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePyrimethamine
-
NoteResearch use only, not for human use.
-
Brief DescriptionA synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.
-
DescriptionA synthetic derivative of ethyl-pyrimidine with potent antimalarial properties; interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR; has also been found to reduce the expression of SOD1.Parasite Infection Approved(In Vitro):Pyrimethamine (Pirimecidan; 4 nM-4 μM; 24 h; LLC-MK2 cells with T. gondii) combination of Fluconazole (FLZ) (HY-B0101) inhibits T. gondii activity with IC50 values of 0.23, 0.19, 0.23, 0.34, 0.14, and 0.19 μM for FLZ concentration at 0, 0.05, 0.1, 0.5, 1.0, and 3.0 μM, respectively.
-
In VitroPyrimethamine (Pirimecidan; 4 nM-4 μM; 24 h; LLC-MK2 cells with T. gondii) combination of Fluconazole (FLZ) (HY-B0101) inhibits T. gondii activity with IC50 values of 0.23, 0.19, 0.23, 0.34, 0.14, and 0.19 μM for FLZ concentration at 0, 0.05, 0.1, 0.5, 1.0, and 3.0 μM, respectively.Cell Viability Assay Cell Line:LLC-MK2 cells with T. gondii Concentration:4 nM-4 μM Incubation Time:24 hours Result:Inhibited T. gondii activity and decreased parasite proliferation index.
-
In VivoPyrimethamine (Pirimecidan; 1 mg/kg; i.g.; daily, for 10 d; female CF1 mice with T. gondii xenograft) combination of Fluconazole (HY-B0101) and Sulfadiazine (HY-B0273) increases protection from death. Animal Model:Female CF1 mice (18-22 g; 4-6 week of age) with T. gondii xenograft Dosage:Oral gavage; daily, for 10 days Administration:1 mg/kg; 10 mg/kg (Fluconazole (HY-B0101)), 40 mg/kg (Sulfadiazine (HY-B0273))Result:Increased mouse survival compared to treatment with SDZ/PYR alone.
-
SynonymsPirimecidan | Pirimetamin | RP 4753
-
PathwayMicrobiology/Virology
-
TargetParasite
-
RecptorDHFR
-
Research AreaInfection
-
IndicationParasite Infection
Chemical Information
-
CAS Number58-14-0
-
Formula Weight248.7114
-
Molecular FormulaC12H13ClN4
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
-
Chemical Name2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lange DJ, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):199-204.
2. Wright PD, et al. Neurosci Lett. 2010 Oct 4;482(3):188-92.
3. Martins-Duarte éS, et al. Exp Parasitol. 2013 Mar;133(3):294-9.
molnova catalog
related products
-
Imidocarb dipropiona...
Imidocarb dipropionate is an antigenic insecticide is active against the protozoan parasite B. bovis (IC50 : 0.87 μg/ml).
-
2-Hydroxy-3,4-dimeth...
2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged between 0.39 and 0.41 μg/mL, which can be used in the study of diabetes, treatment of schistosomiasis, malaria and other infections.
-
UCB7362
UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.
