Physostigmine Salicylate

Research use only, not for human use.

Physostigmine is a parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor.

Physostigmine is a parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. It occurs naturally in the Calabar bean.(In Vivo):Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.

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Animal Model:Heterozygous transgenic mice (Tg(+) mice)Dosage:0.03, 0.1, and 0.3 mg/kg Administration:SC; daily for 6 weeks Result:Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.

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Endocrinology/Hormones

AChR

AChR

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57-64-7

413.48

C22H27N3O5

>98% (HPLC)

DMSO: 10 mM

C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.C1=CC=C(C(=C1)C(=O)O)O

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(-20℃)

With Ice Pack

≥ 2 years