Gabexate mesylate( —— )

Catalog No. M15075 CAS No. 56974-61-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Gabexate mesylate
Note

Research use only, not for human use.
Brief Description

Gabexate Mesylate is a Factor X inhibitor.
Description

Gabexate Mesylate is a Factor X inhibitor.
In Vitro

Cell Proliferation Assay Cell Line:HepG2 cells Concentration:100, 300, and 1000 μM Incubation Time:72 hours Result:The proliferation rate decreased in a dose-dependent manner.
In Vivo

Animal Model:Male Sprague-Dawley rats (100-120 g) with spinal nerve ligation (SNL) Dosage:20 mg/kg Administration:Intraperitoneally; daily; from 3rd day until the 14th day Result:Showed a higher PWT than those of the vehicle-treated group. Markedly decreased the expression of p65. Attenuated the expressions of IL-1, IL-6, and TNF-α at 7th day.
Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

Serine Protease
Recptor

Serine Protease
Research Area

Cardiovascular Disease
Indication

——

CAS Number

56974-61-9
Formula Weight

417.48
Molecular Formula

C17H27N3O7
Purity

>98% (HPLC)
Solubility

Ethanol: 83 mg/mL (198.81 mM); Water: 12 mg/mL (28.74 mM); DMSO: 83 mg/mL (198.81 mM)
SMILES

CS(O)(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCN=C(N)N)C=C1
Chemical Name

——

1.Erba F, et al. Biochem Pharmacol. 2001 Feb 1;61(3):271-6.

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