Naphazoline hydrochloride

Research use only, not for human use.

Naphazoline hydrochloride is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.

Naphazoline hydrochloride is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.(In Vivo):Naphazoline hydrochloride (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF.

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Naphazoline hydrochloride (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF. Animal Model:Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))Dosage:0.2 mg/mL, 10 μl per eye Administration:Intraperitoneal injection (IP), once Result:Significantly suppressed conjunctival dye leakage in mice with histamine or antigen?induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.

2-(1-Naphthylmethyl)-2-imidazoline

Angiogenesis

Adrenergic Receptor

Adrenergic Receptor

Cardiovascular Disease

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550-99-2

246.74

C14H15ClN2

>98% (HPLC)

Ethanol: 22 mg/mL (89.16 mM); Water: 49 mg/mL (198.58 mM); DMSO: 17 mg/mL (68.89 mM)

[H]Cl.C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1

2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride

(-20℃)

With Ice Pack

≥ 2 years