SCH 486757( SCH-486757 | SCH486757 )

Catalog No. M14851 CAS No. 524019-25-8

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Product Name

SCH 486757
Note

Research use only, not for human use.
Brief Description

A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
Description

A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors; effectively suppresses cough in guinea pig capsaicin cough model, without affect on inspiratory electromyogram amplitude.Other Indication Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

SCH-486757 | SCH486757
Pathway

Endocrinology/Hormones
Target

Opioid Receptor
Recptor

Opioid Receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

524019-25-8
Formula Weight

440.368
Molecular Formula

C24H23Cl2N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

ClC1=CC=CC=C1C(N2[C@@H]3CC[C@H]2C[C@](C4=NC=CC=N4)(O)C3)C5=CC=CC=C5Cl
Chemical Name

8-(bis(2-chlorophenyl)methyl)-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol

1. McLeod RL, et al. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20. 2. Woodcock A, et al. Lung. 2010 Jan;188 Suppl 1:S47-52.

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