MIM1( MIM 1 | MIM-1 )

Catalog No. M14748 CAS No. 509102-00-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MIM1
Note

Research use only, not for human use.
Brief Description

A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1.
Description

A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1; effectively competes with FITC-MCL-1 SAHBA and FITC-BID BH3 for MCL-1ΔNΔC binding with IC50 of 4.7 and 4.8 uM, respectively; shows no activity for Bcl-xL; induces caspase activation and leukemia cell death in the specific context of MCL-1 dependence.
In Vitro

MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC50 value. The IC50 value of the HA cell line is almost 5-fold lower (16.10 μM) compared with the IC50 of the T98G cell line (80.20 μM) after MIM-1 inhibitor treatment.
In Vivo

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Synonyms

MIM 1 | MIM-1
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

Cancer
Indication

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CAS Number

509102-00-5
Formula Weight

347.4319
Molecular Formula

C17H21N3O3S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=CSC(=NC2CCCCC2)N1N=CC3=C(C(=C(C=C3)O)O)O
Chemical Name

1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-

1. Cohen NA, et al. Chem Biol. 2012 Sep 21;19(9):1175-86. 2. Habata S, et al. Int J Oncol. 2016 Jul;49(1):402-10.

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