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Home - Products - Cell Cycle/DNA Damage - DNA-PK - KU-57788

KU-57788

CAS No. 503468-95-9

KU-57788( KU 57788 | NU-7441 | KU57788 | NU7441 | NU 7441 )

Catalog No. M14707 CAS No. 503468-95-9

A highly potent and selective DNA-PK inhibitor (IC50=14 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KU-57788
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and selective DNA-PK inhibitor (IC50=14 nM).
  • Description
    A highly potent and selective DNA-PK inhibitor (IC50=14 nM); also modestly inhibits BRD4 and BRDT with IC50 of 1 uM and 3.5 uM respectively; also stimulates Cas9-mediated genome editing.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KU 57788 | NU-7441 | KU57788 | NU7441 | NU 7441
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA-PK
  • Recptor
    ATM|ATR|DNA-PK|mTOR|PI3K
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    503468-95-9
  • Formula Weight
    413.4883
  • Molecular Formula
    C25H19NO3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=CC=C4)C=CC=C13
  • Chemical Name
    4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Leahy JJ, et al. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7. 2. Robert F, et al. Genome Med. 2015 Aug 27;7:93. 3. Ember SW, et al. ACS Chem Biol. 2014 May 16;9(5):1160-71.
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