Estradiol

Research use only, not for human use.

Estradiol (E2) is a potent mammalian estrogenic hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.

Estradiol (E2) is a potent mammalian estrogenic hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.

Cell Differentiation Assay Cell Line:Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration:10 nM Incubation Time:7 days Result:Increased the number of neurite processes including neural differentiation and neurite branching.Immunofluorescence Cell Line:Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration:10 nM Incubation Time:7 days Result:Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.

Animal Model:FBN-ARO-KO Mice Dosage:1 nM Administration:Treated for the hippocampal slices Result:Rescued long-term potentiation (LTP) amplitude of both male and female mice.Animal Model:FBN-ARO-KO Mice Dosage:0.0167 mg Administration:Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.Result:Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.

β-Estradiol | Estradiol | 17β-Oestradiol | E2

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Endocrinology

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50-28-2

272.38

C18H24O2

>98% (HPLC)

Ethanol: 5 mg/mL (18.35 mM); DMSO: 54 mg/mL (198.25 mM)

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

(-20℃)

With Ice Pack

≥ 2 years