Corticosterone

Research use only, not for human use.

Corticosterone is a sensitive inhibitor of monoamine transport.

Corticosterone is a sensitive inhibitor of monoamine transport. (In Vitro):Corticosterone (100 nM; 30 min) via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.Corticosterone (CORT) (1 μM; 48 h) shows good immunosuppressive properties (functionally compromises maturation of BMDC), which impairs LPS-induced up-regulation of maturation-associated markers (MHC class II, B7.2, B7.1 and CD40).(In Vivo):Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8+ T cells in vivo.Corticosterone (0.03 or 1 mg/kg; s.c.; single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats.Corticosterone (2.6 mg/kg; in animal feedings; 8 days) restores ethanol intake and preference to approximately normal preoperative levels in adrenalectomy (ADX) rats.

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17-deoxy Cortisol | 11β,21-DHP | NSC 9705 | 11β,21-dihydroxy Progesterone

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Neurological Disease

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50-22-6

346.46

C21H30O4

>98% (HPLC)

Soluble in DMSO

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

(-20℃)

With Ice Pack

≥ 2 years