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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - AVE-0118

AVE-0118

CAS No. 498577-53-0

AVE-0118( AVE0118 )

Catalog No. M14669 CAS No. 498577-53-0

AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AVE-0118
  • Note
    Research use only, not for human use.
  • Brief Description
    AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM.
  • Description
    AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency; dose-dependently prolongs the atrial refractoriness independent from rate and inhibits left atrial vulnerability (LAV) in vivo; fully restored atrial contraction without proarrhythmic effects on the ventricle.Heart Arrhythmia Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AVE0118
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    498577-53-0
  • Formula Weight
    479.58
  • Molecular Formula
    C30H29N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=CC=C1C2=CC=CC=C2CNC(CC3=CC=C(OC)C=C3)=O)NCCC4=CC=CN=C4
  • Chemical Name
    2'-[[2-(4-Methoxyphenyl)acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Haan S, et al. Circulation. 2006 Sep 19;114(12):1234-42. 2. Decher N, et al. Mol Pharmacol. 2006 Oct;70(4):1204-11. 3. Wettwer E, et al. Circulation. 2004 Oct 19;110(16):2299-306. 4. Wirth KJ, et al. Cardiovasc Res. 2003 Nov 1;60(2):298-306.
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