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Edoxaban (b)
CAS No. 480449-70-5
Edoxaban (b)( DU-176 )
Catalog No. M14605 CAS No. 480449-70-5
A potent and orally active Factor Xa inhibitor with Ki of 0.561 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | Get Quote |
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| 10MG | 57 | Get Quote |
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| 25MG | 84 | Get Quote |
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| 50MG | 106 | Get Quote |
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| 100MG | 148 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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| 5MG | 43 | In Stock |
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| 10MG | 60 | In Stock |
|
| 25MG | 88 | In Stock |
|
| 50MG | 110 | In Stock |
|
| 100MG | 153 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEdoxaban (b)
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and orally active Factor Xa inhibitor with Ki of 0.561 nM.
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DescriptionA potent and orally active Factor Xa inhibitor with Ki of 0.561 nM; also inhibits prothrombinase (Ki=2.98 nM), weakly inhibits thrombin and FIXa (Ki=6.0 uM, and 41.7 uM); exhibits >10,000-fold selectivity for Fxa over FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin and chymotrypsin; inhibits thrombus formation in rat and rabbit thrombosis models.Thrombosis Approved.
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In VitroEdoxaban (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.Cell Viability Assay Cell Line:Human, rat, cynomolgus monkey and rabbit plasma; Human platelet Concentration:Incubation Time:1 and 5 minutes Result:Antithrombin.
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In VivoEdoxaban (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT. Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).Dosage:0.5, 2.5 and 12.5 mg/kg Administration:Oral administration; once Result:Inhibited exogenous FXa activity.
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SynonymsDU-176
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PathwayMetabolic Enzyme/Protease
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TargetFactor Xa
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RecptorFactor Xa
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number480449-70-5
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Formula Weight548.0575
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Molecular FormulaC24H30ClN7O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C
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Chemical NameEthanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Furugohri T, et al. J Thromb Haemost. 2008 Sep;6(9):1542-9.
2. Furugohri T, et al. Eur J Pharmacol. 2012 Jul 5;686(1-3):74-80.
3. Morishima Y, et al. Thromb Res. 2013 Jan;131(1):59-63.
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