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SCH-527123
CAS No. 473727-83-2
SCH-527123( SCH527123 | Navarixin | SCH 527123 | MK-7123 )
Catalog No. M14572 CAS No. 473727-83-2
A potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 81 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 310 | In Stock |
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| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1004 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSCH-527123
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
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DescriptionA potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively; potently inhibits CXCR2-mediated chemotaxis with IC50 of 3-6 nM; inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.COPD Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsSCH527123 | Navarixin | SCH 527123 | MK-7123
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number473727-83-2
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Formula Weight397.4244
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Molecular FormulaC21H23N3O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N(C)C)C1=CC=CC(NC2=C(N[C@@H](C3=CC=C(C)O3)CC)C(C2=O)=O)=C1O
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Chemical NameBenzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chapman RW, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):486-93.
2. Dwyer MP, et al. J Med Chem. 2006 Dec 28;49(26):7603-6.
3. Gonsiorek W, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):477-85.
4. Singh S, et al. Clin Cancer Res. 2009 Apr 1;15(7):2380-6.
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