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EMD-281014 hydrochloride

CAS No. 443144-27-2

EMD-281014 hydrochloride( Pruvanserin | LSN2411347 | LY-2422347 )

Catalog No. M14513 CAS No. 443144-27-2

EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    EMD-281014 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM.
  • Description
    EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels; significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test; reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset.Sleep Disorder Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pruvanserin | LSN2411347 | LY-2422347
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    443144-27-2
  • Formula Weight
    412.893
  • Molecular Formula
    C22H22ClFN4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CCN1CCC2=CC=C(C=C2)F)C(=O)C3=CC=CC4=C3NC=C4C#N.Cl
  • Chemical Name
    7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hamadjida A, et al. Neuropharmacology. 2018 Jun 30;139:61-67. 2. Lauffer L, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):39-49. 3. Patel JG, et al. Synapse. 2004 Apr;52(1):73-5. 4. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4.
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