Anguizole( Anguizole )

Catalog No. M14509 CAS No. 442666-98-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Anguizole
Note

Research use only, not for human use.
Brief Description

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2).
Description

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM; disrupts NS4B-AH2-mediated biological functions of NS4B, NS4B's dimerization/multimerization, its proper subcellular localization, as well as its interaction with NS5A.
In Vitro

——
In Vivo

——
Synonyms

Anguizole
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

Infection
Indication

——

CAS Number

442666-98-0
Formula Weight

408.8078
Molecular Formula

C17H11ClF2N4O2S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C1=NN2C(C(F)(Cl)F)=CC(C3=CC=CO3)=NC2=C1)NCC4=CC=CS4
Chemical Name

Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-

1. Choi M, et al. Virus Genes. 2013 Dec;47(3):395-407.

Calculator

molnova catalog