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ASP 9853

CAS No. 442198-67-6

ASP 9853( ASP9853 | ASP-9853 | FR 260330 dehydrate )

Catalog No. M14503 CAS No. 442198-67-6

A potent, orally active iNOS inhibitor that prevents dimerization of iNOS.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ASP 9853
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active iNOS inhibitor that prevents dimerization of iNOS.
  • Description
    A potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS; reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure; also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.Blood Cancer Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ASP9853 | ASP-9853 | FR 260330 dehydrate
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    NOS
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    442198-67-6
  • Formula Weight
    617.026
  • Molecular Formula
    C29H28ClF3N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CCC1OC2=NC=NC(=C2)C(F)(F)F)C(=O)CNC(=O)C(CC3=CC=CC=N3)NC(=O)C=CC4=CC=C(C=C4)Cl
  • Chemical Name
    (S,E)-3-(4-chlorophenyl)-N-(1-oxo-1-((2-oxo-2-(4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)ethyl)amino)-3-(pyridin-2-yl)propan-2-yl)acrylamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58. 2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6.
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