ASP 9853( ASP9853 | ASP-9853 | FR 260330 dehydrate )

Catalog No. M14503 CAS No. 442198-67-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

ASP 9853
Note

Research use only, not for human use.
Brief Description

A potent, orally active iNOS inhibitor that prevents dimerization of iNOS.
Description

A potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS; reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure; also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.Blood Cancer Phase 1 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

ASP9853 | ASP-9853 | FR 260330 dehydrate
Pathway

Immunology/Inflammation
Target

NOS
Recptor

NOS
Research Area

Cancer
Indication

Blood cancer

CAS Number

442198-67-6
Formula Weight

617.026
Molecular Formula

C29H28ClF3N6O4
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CN(CCC1OC2=NC=NC(=C2)C(F)(F)F)C(=O)CNC(=O)C(CC3=CC=CC=N3)NC(=O)C=CC4=CC=C(C=C4)Cl
Chemical Name

(S,E)-3-(4-chlorophenyl)-N-(1-oxo-1-((2-oxo-2-(4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)ethyl)amino)-3-(pyridin-2-yl)propan-2-yl)acrylamide

1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58. 2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6.

Calculator

molnova catalog