Cart
sales@molnova.com
Home - Products - Immunology/Inflammation - NOS - ASP 9853

ASP 9853

CAS No. 442198-67-6

ASP 9853( ASP9853 | ASP-9853 | FR 260330 dehydrate )

Catalog No. M14503 CAS No. 442198-67-6

A potent, orally active iNOS inhibitor that prevents dimerization of iNOS.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
5MG 459 In Stock
10MG 657 In Stock
25MG 1026 In Stock
50MG 1386 In Stock
100MG 1832 In Stock
200MG Get Quote In Stock
500MG 3655 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ASP 9853
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active iNOS inhibitor that prevents dimerization of iNOS.
  • Description
    A potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS; reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure; also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.Blood Cancer Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ASP9853 | ASP-9853 | FR 260330 dehydrate
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    NOS
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    442198-67-6
  • Formula Weight
    617.026
  • Molecular Formula
    C29H28ClF3N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CCC1OC2=NC=NC(=C2)C(F)(F)F)C(=O)CNC(=O)C(CC3=CC=CC=N3)NC(=O)C=CC4=CC=C(C=C4)Cl
  • Chemical Name
    (S,E)-3-(4-chlorophenyl)-N-(1-oxo-1-((2-oxo-2-(4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)ethyl)amino)-3-(pyridin-2-yl)propan-2-yl)acrylamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58. 2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • nNOS-IN-25

    A potent, selective cell permeable neuronal nitric oxide synthase (nNOS) inhibitor with Ki of 30 nM.

  • Dactylorhin A

    Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea.?Dactylorhin A exhibits moderate inhibitory effect on NO production effects in RAW 264.7 macrophage cells.

  • Syringin

    Syringin has antitumour, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects. Syringin can prevent Abeta(25-35)-induced neuronal cell damage.

Sign In Join Free